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When a meteorite from outer space hits a young Californian girl named Susan Murphy (Reese Witherspoon) and turns her into a giant monster, she is taken to a secret government compound where she meets a ragtag group of monsters, also rounded up over the years. As a last resort, under the guidance of General W.R. Monger (Kiefer Sutherland), the motley crew of Monsters is called into action to combat the aliens and save the world from imminent destruction!

Adapted from the novel "Angels and Demons" by Dan Brown, the film follows the story of Robert Langdon, a well-known Harvard symbologist investigating a murder victim, branded with the Illuminati ambigram. Following his investigation, he soon discovers that a cult group is on a trail to murder four cardinals and destroy the St. Peter's Basilica during a papal gathering.